The immune gene repertoire of an important viral reservoir, the Australian black flying fox.
Identifieur interne : 001C36 ( Main/Exploration ); précédent : 001C35; suivant : 001C37The immune gene repertoire of an important viral reservoir, the Australian black flying fox.
Auteurs : Anthony T. Papenfuss [Australie] ; Michelle L. Baker ; Zhi-Ping Feng ; Mary Tachedjian ; Gary Crameri ; Chris Cowled ; Justin Ng ; Vijaya Janardhana ; Hume E. Field ; Lin-Fa WangSource :
- BMC genomics [ 1471-2164 ] ; 2012.
Descripteurs français
- KwdFr :
- ARN messager (génétique), ARN messager (métabolisme), Alignement de séquences, Animaux, Annotation de séquence moléculaire, Antigènes d'histocompatibilité (), Antigènes d'histocompatibilité (génétique), Australie, Chiroptera (génétique), Chiroptera (immunologie), Chiroptera (virologie), Données de séquences moléculaires, Equus caballus (génétique), Humains, Immunité acquise (génétique), Immunité innée (génétique), Phylogénie, Récepteurs immunologiques (), Récepteurs immunologiques (génétique), Récepteurs immunologiques (métabolisme), Réservoirs d'agents pathogènes (virologie), Similitude de séquences d'acides nucléiques, Système immunitaire (métabolisme), Séquence conservée (génétique), Séquence d'acides aminés, Transcriptome (génétique), Vecteurs de maladie.
- MESH :
- génétique : ARN messager, Antigènes d'histocompatibilité, Chiroptera, Equus caballus, Immunité acquise, Immunité innée, Récepteurs immunologiques, Séquence conservée, Transcriptome.
- immunologie : Chiroptera.
- métabolisme : ARN messager, Récepteurs immunologiques, Système immunitaire.
- virologie : Chiroptera, Réservoirs d'agents pathogènes.
- Alignement de séquences, Animaux, Annotation de séquence moléculaire, Antigènes d'histocompatibilité, Australie, Données de séquences moléculaires, Humains, Phylogénie, Récepteurs immunologiques, Similitude de séquences d'acides nucléiques, Séquence d'acides aminés, Vecteurs de maladie.
- Wicri :
- geographic : Australie.
English descriptors
- KwdEn :
- Adaptive Immunity (genetics), Amino Acid Sequence, Animals, Australia, Chiroptera (genetics), Chiroptera (immunology), Chiroptera (virology), Conserved Sequence (genetics), Disease Reservoirs (virology), Disease Vectors, Histocompatibility Antigens (chemistry), Histocompatibility Antigens (genetics), Horses (genetics), Humans, Immune System (metabolism), Immunity, Innate (genetics), Molecular Sequence Annotation, Molecular Sequence Data, Phylogeny, RNA, Messenger (genetics), RNA, Messenger (metabolism), Receptors, Immunologic (chemistry), Receptors, Immunologic (genetics), Receptors, Immunologic (metabolism), Sequence Alignment, Sequence Homology, Nucleic Acid, Transcriptome (genetics).
- MESH :
- chemical , chemistry : Histocompatibility Antigens, Receptors, Immunologic.
- chemical , genetics : Histocompatibility Antigens, RNA, Messenger, Receptors, Immunologic.
- chemical , metabolism : RNA, Messenger, Receptors, Immunologic.
- geographic : Australia.
- genetics : Adaptive Immunity, Chiroptera, Conserved Sequence, Horses, Immunity, Innate, Transcriptome.
- immunology : Chiroptera.
- metabolism : Immune System.
- virology : Chiroptera, Disease Reservoirs.
- Amino Acid Sequence, Animals, Disease Vectors, Humans, Molecular Sequence Annotation, Molecular Sequence Data, Phylogeny, Sequence Alignment, Sequence Homology, Nucleic Acid.
Abstract
Bats are the natural reservoir host for a range of emerging and re-emerging viruses, including SARS-like coronaviruses, Ebola viruses, henipaviruses and Rabies viruses. However, the mechanisms responsible for the control of viral replication in bats are not understood and there is little information available on any aspect of antiviral immunity in bats. Massively parallel sequencing of the bat transcriptome provides the opportunity for rapid gene discovery. Although the genomes of one megabat and one microbat have now been sequenced to low coverage, no transcriptomic datasets have been reported from any bat species. In this study, we describe the immune transcriptome of the Australian flying fox, Pteropus alecto, providing an important resource for identification of genes involved in a range of activities including antiviral immunity.
DOI: 10.1186/1471-2164-13-261
PubMed: 22716473
Affiliations:
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Baker</name></author><author><name sortKey="Feng, Zhi Ping" sort="Feng, Zhi Ping" uniqKey="Feng Z" first="Zhi-Ping" last="Feng">Zhi-Ping Feng</name></author><author><name sortKey="Tachedjian, Mary" sort="Tachedjian, Mary" uniqKey="Tachedjian M" first="Mary" last="Tachedjian">Mary Tachedjian</name></author><author><name sortKey="Crameri, Gary" sort="Crameri, Gary" uniqKey="Crameri G" first="Gary" last="Crameri">Gary Crameri</name></author><author><name sortKey="Cowled, Chris" sort="Cowled, Chris" uniqKey="Cowled C" first="Chris" last="Cowled">Chris Cowled</name></author><author><name sortKey="Ng, Justin" sort="Ng, Justin" uniqKey="Ng J" first="Justin" last="Ng">Justin Ng</name></author><author><name sortKey="Janardhana, Vijaya" sort="Janardhana, Vijaya" uniqKey="Janardhana V" first="Vijaya" last="Janardhana">Vijaya Janardhana</name></author><author><name sortKey="Field, Hume E" sort="Field, Hume E" uniqKey="Field H" first="Hume E" last="Field">Hume E. 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Field</name></author><author><name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name></author></analytic><series><title level="j">BMC genomics</title><idno type="eISSN">1471-2164</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptive Immunity (genetics)</term><term>Amino Acid Sequence</term><term>Animals</term><term>Australia</term><term>Chiroptera (genetics)</term><term>Chiroptera (immunology)</term><term>Chiroptera (virology)</term><term>Conserved Sequence (genetics)</term><term>Disease Reservoirs (virology)</term><term>Disease Vectors</term><term>Histocompatibility Antigens (chemistry)</term><term>Histocompatibility Antigens (genetics)</term><term>Horses (genetics)</term><term>Humans</term><term>Immune System (metabolism)</term><term>Immunity, Innate (genetics)</term><term>Molecular Sequence 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System</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term><term>Récepteurs immunologiques</term><term>Système immunitaire</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term><term>Réservoirs d'agents pathogènes</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term><term>Disease Reservoirs</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Disease Vectors</term><term>Humans</term><term>Molecular Sequence Annotation</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Sequence Alignment</term><term>Sequence Homology, Nucleic Acid</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term><term>Animaux</term><term>Annotation de séquence moléculaire</term><term>Antigènes d'histocompatibilité</term><term>Australie</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Phylogénie</term><term>Récepteurs immunologiques</term><term>Similitude de séquences d'acides nucléiques</term><term>Séquence d'acides aminés</term><term>Vecteurs de maladie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Australie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bats are the natural reservoir host for a range of emerging and re-emerging viruses, including SARS-like coronaviruses, Ebola viruses, henipaviruses and Rabies viruses. However, the mechanisms responsible for the control of viral replication in bats are not understood and there is little information available on any aspect of antiviral immunity in bats. Massively parallel sequencing of the bat transcriptome provides the opportunity for rapid gene discovery. Although the genomes of one megabat and one microbat have now been sequenced to low coverage, no transcriptomic datasets have been reported from any bat species. In this study, we describe the immune transcriptome of the Australian flying fox, Pteropus alecto, providing an important resource for identification of genes involved in a range of activities including antiviral immunity.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Baker, Michelle L" sort="Baker, Michelle L" uniqKey="Baker M" first="Michelle L" last="Baker">Michelle L. Baker</name><name sortKey="Cowled, Chris" sort="Cowled, Chris" uniqKey="Cowled C" first="Chris" last="Cowled">Chris Cowled</name><name sortKey="Crameri, Gary" sort="Crameri, Gary" uniqKey="Crameri G" first="Gary" last="Crameri">Gary Crameri</name><name sortKey="Feng, Zhi Ping" sort="Feng, Zhi Ping" uniqKey="Feng Z" first="Zhi-Ping" last="Feng">Zhi-Ping Feng</name><name sortKey="Field, Hume E" sort="Field, Hume E" uniqKey="Field H" first="Hume E" last="Field">Hume E. Field</name><name sortKey="Janardhana, Vijaya" sort="Janardhana, Vijaya" uniqKey="Janardhana V" first="Vijaya" last="Janardhana">Vijaya Janardhana</name><name sortKey="Ng, Justin" sort="Ng, Justin" uniqKey="Ng J" first="Justin" last="Ng">Justin Ng</name><name sortKey="Tachedjian, Mary" sort="Tachedjian, Mary" uniqKey="Tachedjian M" first="Mary" last="Tachedjian">Mary Tachedjian</name><name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name></noCountry><country name="Australie"><noRegion><name sortKey="Papenfuss, Anthony T" sort="Papenfuss, Anthony T" uniqKey="Papenfuss A" first="Anthony T" last="Papenfuss">Anthony T. Papenfuss</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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